Stemolecule™ CHIR99021（GSK-3β抑制劑）

產(chǎn)品關(guān)鍵詞：

GSK-3β；na?ve stem cells 初始干細(xì)胞；neural progenitor cells 神經(jīng)祖細(xì)胞；WH-4-023；Y27632；PD0325901；CAS：252917-06-9；

產(chǎn)品描述：

氨基嘧啶CHIR99021是目前為止報(bào)道的選擇性zui強(qiáng)的GSK-3β抑制劑。與其他強(qiáng)效的GSK-3抑制劑相比，CHIR99021不會(huì)交叉抑制細(xì)胞周期蛋白依賴性激酶（CDKs），對(duì)GSK-3β的選擇性是對(duì)CDKs的350倍。與抑制MAPK來源的分化誘導(dǎo)信號(hào)聯(lián)合，使用CHIR99021阻斷 GSK-3β信號(hào)使得胚胎干細(xì)胞能自我更新。

產(chǎn)品特性

1. 同義名：6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

2. 分子式：C₂₂H₁₈Cl₂N₈

3. 分子量：465.34 g/mol

4. CAS NO：252917-06-9

5. 純度：＞95%（HPLC）

6. 外觀：Off-white solid

7. 溶解性：DMSO

8. 保存和穩(wěn)定性：粉末4 °C避光保存，重溶后的儲(chǔ)存液分裝后-20 °C保存，6個(gè)月穩(wěn)定。

9. 質(zhì)量控制：HPLC測(cè)定純度，MS測(cè)定準(zhǔn)確分子量，CHIR99021對(duì)小鼠胚胎干細(xì)胞的細(xì)胞毒性測(cè)試。

10. 結(jié)構(gòu)圖：

訂購(gòu)信息：原裝好貨，歡迎訂購(gòu)，：，：。

引用文獻(xiàn)：

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• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)

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— —Written/Edited by V. Shallan【版權(quán)歸MKBio懋康所有】

上海懋康生物科技有限公司是一家涉足于生命科學(xué)和生物技術(shù)領(lǐng)域研究的試劑、儀器和實(shí)驗(yàn)室消耗品與實(shí)驗(yàn)服務(wù)工作，主要從事細(xì)胞生物學(xué)、植物學(xué)、分子生物學(xué)、免疫學(xué)、生物化學(xué)、蛋白組學(xué)。生物制藥與診斷試劑研發(fā)生產(chǎn)等領(lǐng)域。 本公司秉承“以人為本，以誠(chéng)為信、合同守信"的經(jīng)營(yíng)理念。堅(jiān)持"品質(zhì)保障"的原則為廣大客戶提供優(yōu)質(zhì)產(chǎn)品。

Stemolecule™ CHIR99021（GSK-3β抑制劑）

Stemolecule™ CHIR99021（GSK-3β抑制劑）

Stemolecule™ CHIR99021（GSK-3β抑制劑）